Clozapine and negative symptoms
نویسندگان
چکیده
منابع مشابه
Clozapine: Improvement of Negative Symptoms of Schizophrenia
We report five cases of treatment-resistant schizophrenia that presented with prominent negative and positive symptoms. They fulfill the criteria of diagnosis of schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). They showed lack of response despite receiving multiple trials of first and second generation psychotropic agents. We decided ...
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Although negative symptoms were traditionally considered to be unresponsive to neuroleptic medication, recent studies have demonstrated that negative symptoms do improve during neuroleptic treatment and that such improvement tends to occur concurrently with improvement in positive symptoms. Clozapine is an atypical neuroleptic that is effective in a significant proportion of otherwise neurolept...
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Although poor response to neuroleptics has traditionally been considered a characteristic feature of negative schizophrenic symptoms, several recent studies have documented significant improvement in negative symptoms in schizophrenic patients treated with neuroleptics. The question of whether neuroleptic-induced improvement in negative symptoms is linked to concomitant improvement in positive ...
متن کاملNegative Symptoms and Negative Schizophrenia
This study determines the frequency distribution of prominent negative symptoms in a group of chronic, hospitalised schizophrenics. Thirty chronic Schizophrenic (D.S.M. III) patients were rated on the scale for Assessment of Negative Symptoms (SANS) and the prominent negative symptoms were correlated with age, sex and certain illness variables. Majority (80%) of patients had some or the other n...
متن کاملWhen symptoms persist: clozapine augmentation strategies.
Recent data and clinical experience confirm that, in spite of superior efficacy for treatment-refractory schizophrenia, a substantial proportion of patients receiving clozapine will continue to experience disabling symptoms. Optimizing clozapine monotherapy is the first step in the management of "clozapine nonresponders." Described here is a synthesis of the available literature on the range an...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 1993
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.163.1.121b